Eyewitnesses say the road remains blocked since 2am.
A truck carrying powdered milk has overturned at Karuma Bridge, blocking the road.
The incident occurred at around 2:30 a.m.
The road remains closed, according to eyewitnesses.
The route remains blocked, with motorists being advised to pass through Masindi Port instead.
Officials are reportedly looking for a crane from Gulu or Kampala to clear the wreckage. Travellers have been urged to stay home or use the Masindi Port ferry until the road is reopened.
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